Novel coronary heart disease risk factors at 60-64 years and life course socioeconomic position: the 1946 British birth cohort.

ABSTRACT: Social disadvantage across the life course is associated with a greater risk of coronary heart disease (CHD) and with established CHD risk factors, but less is known about whether novel CHD risk factors show the same patterns. The Medical Research Council National Survey of Health and Development was used to investigate associations between occupational socioeconomic position during childhood, early adulthood and middle age and markers of inflammation (C-reactive protein, interleukin-6), endothelial function (E-selectin, tissue-plasminogen activator), adipocyte function (leptin, adiponectin) and pancreatic beta cell function (proinsulin) measured at 60-64 years. Life course models representing sensitive periods, accumulation of risk and social mobility were compared with a saturated model

SUBMITTER: Jones R 

PROVIDER: S-EPMC4286122 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature