Comprehensive quantitative analysis of ovarian and breast cancer tumor peptidomes.

ABSTRACT: Aberrant degradation of proteins is associated with many pathological states, including cancers. Mass spectrometric analysis of tumor peptidomes, the intracellular and intercellular products of protein degradation, has the potential to provide biological insights on proteolytic processing in cancer. However, attempts to use the information on these smaller protein degradation products from tumors for biomarker discovery and cancer biology studies have been fairly limited to date, largely due to the lack of effective approaches for robust peptidomics identification and quantification and the prevalence of confounding factors and biases associated with sample handling and processing. Herein, we have developed an effective and robust analytical platform for comprehensive analyses of tissue pe

SUBMITTER: Xu Z 

PROVIDER: S-EPMC4286152 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature