Simultaneous pancreas and kidney transplantation: current trends and future directions.

ABSTRACT:

Purpose of review

Important trends are being observed in pancreas transplantation in the USA. We will describe recent trends in simultaneous pancreas kidney (SPK) transplantation related to immunosuppression, treatment of rejection, and transplantation for patients of advanced age and C-peptide positive diabetes.

Recent findings

Rates of pancreas transplantation have declined, despite improved pancreatic graft outcomes. Regarding immunosuppression, trends in SPK transplantation include T-cell depletion induction therapy, waning mammalian target of rapamycin inhibitor use and steroid use in greater than 50% of pancreas transplant recipients with few patients undergoing late steroid weaning. Rejection of the pancreas may be discordant with the kidney after SPK and there is a g

SUBMITTER: Redfield RR 

PROVIDER: S-EPMC4286161 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature