Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network.

ABSTRACT:

Background and purpose

NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium.

Methods

Fifty-two trained and certified adjudicators determined both phenotypic (abnormal test findings categorized in major pathogenic groups without weighting toward the most likely cause) and causative ischemic stroke subtypes in 16 954 subjects with imaging-confirmed ischemic stroke from 12 US studies and 11 studies from 8 European countries using the web-ba

SUBMITTER: Ay H 

PROVIDER: S-EPMC4286169 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature