Cerebellar morphology in Tourette syndrome and obsessive-compulsive disorder.

ABSTRACT:

Objective

Neuroanatomical and functional imaging studies have identified the cerebellum as an integral component of motor and language control. Few studies, however, have investigated the role of the cerebellum in Tourette syndrome (TS), a condition defined by the presence of semi-involuntary movements and sounds.

Methods

Magnetic resonance imaging was conducted in 163 persons with TS and 147 control participants. Multivariate linear regression models were used to explore effects on cerebellar surface morphology and underlying volumes for the main diagnosis effects of TS as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder. Additionally, the correlations of symptom severity with cerebellar morphology were also assessed.

Resu

SUBMITTER: Tobe RH 

PROVIDER: S-EPMC4286180 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature