Reduced behavioral and neural activation in stimulant users to different error rates during decision making.

ABSTRACT:

Background

Behavioral processes and neural systems dysfunctions that put individuals at risk for drug use in general, and stimulant use in particular, are poorly understood. Here, the hypothesis is examined that stimulant-using subjects adjust their decision making less as a function of errors as evidenced by attenuated behavioral and neural substrate activation patterns.

Methods

Twelve young adults who had used stimulants were compared with 12 education-matched, stimulant-naive comparison subjects. Subjects completed the two-choice prediction task with three fixed error-rate conditions (20%, 50%, or 80% errors) during functional magnetic resonance imaging.

Results

Stimulant users relative to comparison subjects showed less strategy adjustment to different error rates

SUBMITTER: Paulus MP 

PROVIDER: S-EPMC4286246 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature