Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells.

ABSTRACT:

Background

The link between environmental estrogen exposure and defects in the female reproductive tract is well established. The phytoestrogen genistein is able to modulate uterine estrogen receptor (ER) activity, and dietary exposure is associated with uterine pathologies. Regulation of stress and immune functions by the glucocorticoid receptor (GR) is also an integral part of maintaining reproductive tract function; disruption of GR signaling by genistein may also have a role in the adverse effects of genistein.

Objective

We evaluated the transcriptional response to genistein in Ishikawa cells and investigated the effects of genistein on GR-mediated target genes.

Methods

We used Ishikawa cells as a model system to identify novel targets of genistein and the synthet

SUBMITTER: Whirledge S 

PROVIDER: S-EPMC4286279 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature