Ontology highlight
ABSTRACT:
SUBMITTER: Ellingsgaard H
PROVIDER: S-EPMC4286294 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Nature medicine 20111030 11
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin secretion. Here we show that administration of IL-6 or elevated IL-6 concentrations in response to exercise stimulate GLP-1 secretion from intestinal L cells and pancreatic alpha cells, improving insulin secretion and glycemia. IL-6 increased GLP-1 production from alpha cells through increased proglucagon (which is enc ...[more]