Use of granulocyte colony-stimulating factor during pregnancy in women with chronic neutropenia.

ABSTRACT:

Objective

To report outcomes associated with the administration of granulocyte colony-stimulating factor (G-CSF) to women with chronic neutropenia during pregnancy.

Methods

We conducted an observational study of women of childbearing potential with congenital, cyclic, idiopathic, or autoimmune neutropenia enrolled in the Severe Chronic Neutropenia International Registry to determine outcomes of pregnancies, without and with chronic G-CSF therapy, 1999-2014. Treatment decisions were made by the patients' personal physicians. A research nurse conducted telephone interviews of all enrolled U.S. women of childbearing potential using a standard questionnaire. Comparisons used Fisher's exact test analysis and Student's t test.

Results

One hundred seven women reported 224 pr

SUBMITTER: Boxer LA 

PROVIDER: S-EPMC4286310 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature