Effects of BRCA1- and BRCA2-related mutations on ovarian and breast cancer survival: a meta-analysis.

ABSTRACT:

Purpose

To estimate the effects of BRCA1 and BRCA2 mutations on ovarian cancer and breast cancer survival.

Experimental design

We searched PubMed and EMBASE for studies that evaluated the associations between BRCA mutations and ovarian or breast cancer survival. Meta-analysis was conducted to generate combined HRs with 95% confidence intervals (CI) for overall survival (OS) and progression-free survival (PFS).

Results

From 1,201 unique citations, we identified 27 articles that compared prognosis between BRCA mutation carriers and noncarriers in patients with ovarian or breast cancer. Fourteen studies examined ovarian cancer survival and 13 studies examined breast cancer survival. For ovarian cancer, meta-analysis demonstrated that both BRCA1 and BRCA2 mutation carrier

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC4286460 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature