Project description:We present a long-read, single-molecule mapping technology that generates hybrid genetic/epigenetic profiles of native chromosomal DNA. The genome-wide distribution of 5-hmC in human peripheral blood cells correlates well with 5-hmC DNA immunoprecipitation (hMeDIP) sequencing. However, the long single-molecule read-length of 100 kbp-1 Mbp produces 5-hmC profiles across variable genomic regions that failed to show up in the sequencing data. In addition, optical 5-hmC mapping shows a strong correlation between the 5-hmC density in gene bodies and the corresponding level of gene expression.

2018-06-08 | GSE115454 | GEO

Ordered arrays of nanoporous gold nanoparticles.

Project description: Not available

| S-EPMC3458611 | biostudies-literature

Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays.

Project description: Not available

| S-EPMC4701098 | biostudies-literature

Self-assembly of ordered graphene nanodot arrays.

Project description: Not available

| S-EPMC5491516 | biostudies-literature

Densely charged polyelectrolyte-stuffed nanochannel arrays for power generation from salinity gradient.

Project description: Not available