Identification of constrained cancer driver genes based on mutation timing.

ABSTRACT: Cancer drivers are genomic alterations that provide cells containing them with a selective advantage over their local competitors, whereas neutral passengers do not change the somatic fitness of cells. Cancer-driving mutations are usually discriminated from passenger mutations by their higher degree of recurrence in tumor samples. However, there is increasing evidence that many additional driver mutations may exist that occur at very low frequencies among tumors. This observation has prompted alternative methods for driver detection, including finding groups of mutually exclusive mutations and incorporating prior biological knowledge about gene function or network structure. Dependencies among drivers due to epistatic interactions can also result in low mutation frequencies, but this effec

SUBMITTER: Sakoparnig T 

PROVIDER: S-EPMC4287396 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature