Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection.

ABSTRACT:

Background

Respiratory epithelial cells are the primary target of influenza virus infection in human. However, the molecular mechanisms of airway epithelial cell responses to viral infection are not fully understood. Revealing genome-wide transcriptional and post-transcriptional regulatory relationships can further advance our understanding of this problem, which motivates the development of novel and more efficient computational methods to simultaneously infer the transcriptional and post-transcriptional regulatory networks.

Results

Here we propose a novel framework named SITPR to investigate the interactions among transcription factors (TFs), microRNAs (miRNAs) and target genes. Briefly, a background regulatory network on a genome-wide scale (~23,000 nodes and ~370,000 pot

SUBMITTER: Liu ZP 

PROVIDER: S-EPMC4287445 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature