A regulatory hierarchy controls the dynamic transcriptional response to extreme oxidative stress in archaea.

ABSTRACT: Networks of interacting transcription factors are central to the regulation of cellular responses to abiotic stress. Although the architecture of many such networks has been mapped, their dynamic function remains unclear. Here we address this challenge in archaea, microorganisms possessing transcription factors that resemble those of both eukaryotes and bacteria. Using genome-wide DNA binding location analysis integrated with gene expression and cell physiological data, we demonstrate that a bacterial-type transcription factor (TF), called RosR, and five TFIIB proteins, homologs of eukaryotic TFs, combinatorially regulate over 100 target genes important for the response to extremely high levels of peroxide. These genes include 20 other transcription factors and oxidative damage repair gene

SUBMITTER: Tonner PD 

PROVIDER: S-EPMC4287449 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature