Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine.

ABSTRACT: Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an area of increasing study in HIV vaccinology. To date, the efficacy of centralized immunogens has not been evaluated in the context of an animal model that could provide both immunogenicity and protective efficacy data. We previously reported on a live-attenuated (attenuated) equine infectious anemia (EIAV) virus vaccine, which provides 100% protection from disease after virulent, homologous, virus challenge. Further, protective efficacy demonstrated a significant, inverse, linear relationship between EIAV Env divergence and protection from

SUBMITTER: Craigo JK 

PROVIDER: S-EPMC4287611 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature