Intravenous versus intra-arterial thrombolysis in ischemic stroke: a systematic review and meta-analysis.

ABSTRACT:

Background

Reperfusion following ischemic stroke can be attained by either intravenous thrombolysis (IVT) or intra-arterial thrombolysis (IAT). Only a limited number of randomized prospective studies have compared the efficacy and safety of IVT and IAT. This meta-analysis investigated possible clinical benefits of IAT relative to IVT in patients with acute ischemic stroke.

Methods

We searched the PubMed, Cochrane, and Google Scholar databases through October 2013 for manuscripts that describe the findings of randomized controlled or prospective studies that evaluated the outcomes of patients with ischemic stroke who were treated with IVT or IAT. The clinical outcome measures were score on the modified Rankin scale (mRS) and mortality at 90 days. A favorable outcome was defin

SUBMITTER: Ma QF 

PROVIDER: S-EPMC4287629 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature