A highly efficient approach to protein interactome mapping based on collaborative filtering framework.

ABSTRACT: The comprehensive mapping of protein-protein interactions (PPIs) is highly desired for one to gain deep insights into both fundamental cell biology processes and the pathology of diseases. Finely-set small-scale experiments are not only very expensive but also inefficient to identify numerous interactomes despite their high accuracy. High-throughput screening techniques enable efficient identification of PPIs; yet the desire to further extract useful knowledge from these data leads to the problem of binary interactome mapping. Network topology-based approaches prove to be highly efficient in addressing this problem; however, their performance deteriorates significantly on sparse putative PPI networks. Motivated by the success of collaborative filtering (CF)-based approaches to the problem

SUBMITTER: Luo X 

PROVIDER: S-EPMC4287731 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature