BTNL2 gene SNPs as a contributing factor to sarcoidosis pathogenesis in a cohort of Greek patients.

ABSTRACT: Sarcoidosis is a multisystemic granulomatous disease of unknown etiology that primarily affects adults between the ages of 20 and 40 years old. It is characterized by the activation of Th1 lymphocytes resulting in the production of inflammatory cytokines and the formation of noncaseating epithelioid cell granulomas in affected tissues. The lungs and lymphatic system are the ones most frequently affected. The disease usually presents spontaneous remission in the first two years and, in a few patients, the disease progresses to pulmonary fibrosis or other fatal complications depending on the affected organ. The pathogenesis of sarcoidosis is still not clearly defined, and is considered an interaction between the environment and risk alleles in many genes. The present case control study consi

SUBMITTER: Delaveri A 

PROVIDER: S-EPMC4287805 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature