Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people.

ABSTRACT:

Background

MLL5, a member of the histone-lysine N-methyltransferase family, has been implicated in the control of the cell cycle progression and survival. The aim of this study was to explore the relationship between the interaction of histone-lysine N-methyltransferase MLL5 gene polymorphism and CAD in a Chinese Han population.

Methods

Using a case-control study of Chinese CAD patients (n = 565) and healthy controls (n = 694), we investigated the MLL5 gene polymorphism by the use of polymerase chain reaction fragment length polymorphism (PCR-RFLP) analysis.

Results

For total, the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) genotypes showed a significant difference between CAD and control participants (P1 = 0.03, P2 = 0.02). For total the distribution of SN

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC4287819 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature