Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.

ABSTRACT:

Background

Abnormal lipid levels are considered one of the most significant risk factors for atherosclerosis and coronary artery disease, two of the main causes of death worldwide. Apart from monogenic cases of hypercholesterolemia, most of the common dyslipidemias are caused by a number of low-impact polymorphisms. It has recently been reported that frequent polymorphisms at a large number of loci are significantly associated with one or more blood lipid parameters in many populations. Identifying these associations in different populations and estimating the possible interactions between genetic models are necessary to explain the underlying genetic architecture of the associated loci and their ultimate impact on lipid-associated traits.

Methods

We estimated the associatio

SUBMITTER: Radovica I 

PROVIDER: S-EPMC4287865 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature