A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
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ABSTRACT:
SUBMITTER: Vijai J
PROVIDER: S-EPMC4287989 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
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A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Vijai Joseph J Wang Zhaoming Z Berndt Sonja I SI Skibola Christine F CF Slager Susan L SL de Sanjose Silvia S Melbye Mads M Glimelius Bengt B Bracci Paige M PM Conde Lucia L Birmann Brenda M BM Wang Sophia S SS Brooks-Wilson Angela R AR Lan Qing Q de Bakker Paul I W PI Vermeulen Roel C H RC Portlock Carol C Ansell Stephen M SM Link Brian K BK Riby Jacques J North Kari E KE Gu Jian J Hjalgrim Henrik H Cozen Wendy W Becker Nikolaus N Teras Lauren R LR Spinelli John J JJ Turner Jenny J Zhang Yawei Y Purdue Mark P MP Giles Graham G GG Kelly Rachel S RS Zeleniuch-Jacquotte Anne A Ennas Maria Grazia MG Monnereau Alain A Bertrand Kimberly A KA Albanes Demetrius D Lightfoot Tracy T Yeager Meredith M Chung Charles C CC Burdett Laurie L Hutchinson Amy A Lawrence Charles C Montalvan Rebecca R Liang Liming L Huang Jinyan J Ma Baoshan B Villano Danylo J DJ Maria Ann A Corines Marina M Thomas Tinu T Novak Anne J AJ Dogan Ahmet A Liebow Mark M Thompson Carrie A CA Witzig Thomas E TE Habermann Thomas M TM Weiner George J GJ Smith Martyn T MT Holly Elizabeth A EA Jackson Rebecca D RD Tinker Lesley F LF Ye Yuanqing Y Adami Hans-Olov HO Smedby Karin E KE De Roos Anneclaire J AJ Hartge Patricia P Morton Lindsay M LM Severson Richard K RK Benavente Yolanda Y Boffetta Paolo P Brennan Paul P Foretova Lenka L Maynadie Marc M McKay James J Staines Anthony A Diver W Ryan WR Vajdic Claire M CM Armstrong Bruce K BK Kricker Anne A Zheng Tongzhang T Holford Theodore R TR Severi Gianluca G Vineis Paolo P Ferri Giovanni M GM Ricco Rosalia R Miligi Lucia L Clavel Jacqueline J Giovannucci Edward E Kraft Peter P Virtamo Jarmo J Smith Alex A Kane Eleanor E Roman Eve E Chiu Brian C H BC Fraumeni Joseph F JF Wu Xifeng X Cerhan James R JR Offit Kenneth K Chanock Stephen J SJ Rothman Nathaniel N Nieters Alexandra A
Nature communications 20150108
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. ...[more]
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