Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

ABSTRACT: Vertebrates produce various chondroitin sulfate proteoglycans (CSPGs) that are important structural components of cartilage and other connective tissues. CSPGs also contribute to the regulation of more specialized processes such as neurogenesis and angiogenesis. Although many aspects of CSPGs have been studied extensively, little is known of where the CS chains are attached on the core proteins and so far, only a limited number of CSPGs have been identified. Obtaining global information on glycan structures and attachment sites would contribute to our understanding of the complex proteoglycan structures and may also assist in assigning CSPG specific functions. In the present work, we have developed a glycoproteomics approach that characterizes CS linkage regions, attachment sites, and iden

SUBMITTER: Noborn F 

PROVIDER: S-EPMC4288262 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature