Predicting copper-, iron-, and zinc-binding proteins in pathogenic species of the Paracoccidioides genus.

ABSTRACT: Approximately one-third of all proteins have been estimated to contain at least one metal cofactor, and these proteins are referred to as metalloproteins. These represent one of the most diverse classes of proteins, containing metal ions that bind to specific sites to perform catalytic, regulatory and structural functions. Bioinformatic tools have been developed to predict metalloproteins encoded by an organism based only on its genome sequence. Its function and the type of metal binder can also be predicted via a bioinformatics approach. Paracoccidioides complex includes termodimorphic pathogenic fungi that are found as saprobic mycelia in the environment and as yeast, the parasitic form, in host tissues. They are the etiologic agents of Paracoccidioidomycosis, a prevalent systemic mycosi

SUBMITTER: Tristao GB 

PROVIDER: S-EPMC4288321 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature