Association of the variants in the PPARG gene and serum lipid levels: a meta-analysis of 74 studies.

ABSTRACT: Considerable studies have been carried out to investigate the relationship between the polymorphisms of PPARG (Pro12Ala, C161T and C1431T) and serum lipid levels, but the results were inconclusive. Hence, we conducted a meta-analysis to clarify the association. MEDLINE, EMBASE and the Cochrane Library databases were searched systematically. The subgroup analysis was performed based on ethnicity. Seventy-four studies with 54,953 subjects were included in this meta-analysis. In Pro12Ala, the group with the 'PP' (C/C genotype) genotype group had lower levels of total cholesterol (TC) (mean difference, MD: -0.02, P < 0.00001; I(2) = 28%), low-density lipoprotein cholesterol (LDL-C) (MD: -0.02, P < 0.00001; I(2) = 30%) and higher levels of triglyceride (TG) (MD: 0.06, P < 0.00001; I(2) = 30%) t

SUBMITTER: Li Q 

PROVIDER: S-EPMC4288363 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature