Localizing seizure-susceptible brain regions associated with low-grade gliomas using voxel-based lesion-symptom mapping.

ABSTRACT:

Background

Patients afflicted with low-grade glioma (LGG) frequently suffer from seizures. The mechanisms of seizure initiation in these patients remain poorly understood. Tumor location has been correlated with seizure initiation. However, these correlative studies relied on dichotomized data analysis based on arbitrary lobe assignments. As a result, the lesion-symptom correlation may be incorrectly interpreted. Here, we present the first study that used a voxel-wise quantitative lesion analysis to investigate the spatial correlation between tumor location and seizure susceptibility.

Methods

We collected the medical records and magnetic resonance images of 410 LGG patients. The dataset was divided into a discovery set and a validation set. A voxel-based lesion-symptom corre

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4288515 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature