Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.

ABSTRACT:

Background

The current therapy for glioblastoma multiforme (GBM), the most aggressive and common primary brain tumor of adults, involves surgery and a combined radiochemotherapy that controls tumor progression only for a limited time window. Therefore, the identification of new molecular targets is highly necessary. Inhibition of kinases has become a standard of clinical oncology, and thus the oncogenic kinase Pim1 might represent a promising target for improvement of GBM therapy.

Methods

Expression of Pim1 and associated signaling molecules was analyzed in human GBM samples, and the potential role of this kinase in patients' prognosis was evaluated. Furthermore, we analyzed the in vivo role of Pim1 in GBM cell growth in an orthotopic mouse model and examined the consequence

SUBMITTER: Herzog S 

PROVIDER: S-EPMC4288523 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature