Detecting temporal protein complexes from dynamic protein-protein interaction networks.

ABSTRACT:

Background

Proteins dynamically interact with each other to perform their biological functions. The dynamic operations of protein interaction networks (PPI) are also reflected in the dynamic formations of protein complexes. Existing protein complex detection algorithms usually overlook the inherent temporal nature of protein interactions within PPI networks. Systematically analyzing the temporal protein complexes can not only improve the accuracy of protein complex detection, but also strengthen our biological knowledge on the dynamic protein assembly processes for cellular organization.

Results

In this study, we propose a novel computational method to predict temporal protein complexes. Particularly, we first construct a series of dynamic PPI networks by joint analysis of t

SUBMITTER: Ou-Yang L 

PROVIDER: S-EPMC4288635 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature