Genome-wide analyses in bacteria show small-RNA enrichment for long and conserved intergenic regions.

ABSTRACT: Interest in finding small RNAs (sRNAs) in bacteria has significantly increased in recent years due to their regulatory functions. Development of high-throughput methods and more sophisticated computational algorithms has allowed rapid identification of sRNA candidates in different species. However, given their various sizes (50 to 500 nucleotides [nt]) and their potential genomic locations in the 5' and 3' untranslated regions as well as in intergenic regions, identification and validation of true sRNAs have been challenging. In addition, the evolution of bacterial sRNAs across different species continues to be puzzling, given that they can exert similar functions with various sequences and structures. In this study, we analyzed the enrichment patterns of sRNAs in 13 well-annotated bacteri

SUBMITTER: Tsai CH 

PROVIDER: S-EPMC4288687 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature