Genetics of Path Lengths in Brain Connectivity Networks: HARDI-Based Maps in 457 Adults.

ABSTRACT: Brain connectivity analyses are increasingly popular for investigating organization. Many connectivity measures including path lengths are generally defined as the number of nodes traversed to connect a node in a graph to the others. Despite its name, path length is purely topological, and does not take into account the physical length of the connections. The distance of the trajectory may also be highly relevant, but is typically overlooked in connectivity analyses. Here we combined genotyping, anatomical MRI and HARDI to understand how our genes influence the cortical connections, using whole-brain tractography. We defined a new measure, based on Dijkstra's algorithm, to compute path lengths for tracts connecting pairs of cortical regions. We compiled these measures into matrices where e

SUBMITTER: Jahanshad N 

PROVIDER: S-EPMC4288784 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature