HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways.

ABSTRACT:

Objective

To study the cytokine/chemokine profiles in response to HIV-1 viremia, and elucidate the pathways leading to HIV-1-induced inflammation.

Design/methods

Plasma levels of 19 cytokines in individuals with early HIV-1 infection and individuals undergoing treatment interruptions were evaluated via multiplex assay. To investigate the cellular sources of relevant cytokines, sorted cells from HIV-1 infected individuals were assessed for mRNA expression. Relevant signaling pathways were assessed by comparing cytokine production patterns of peripheral blood mononuclear cells stimulated with intact HIV-1 or specific Toll-like receptor (TLR) stimulants with and without a TLR7/9 antagonist.

Results

IP-10 plasma concentration was most significantly associated with HIV-1 v

SUBMITTER: Simmons RP 

PROVIDER: S-EPMC4288813 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature