Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept.

ABSTRACT:

Background

Exercise capacity following Fontan surgery is often depressed. An inability to reduce pulmonary vascular resistance appropriately during exercise may contribute to this phenomenon. The aim of this study was to determine whether administration of iloprost, a selective pulmonary vasodilator, would improve exercise function after Fontan procedure.

Methods

Double-blind, randomized, placebo controlled, crossover trial. Patients performed two cardiopulmonary exercise tests (CPX) separated by <1 month. A single nebulizer treatment (iloprost or placebo) was administered before each CPX.

Results

18 patients aged 12-49 (median 17) years were recruited. Mild throat discomfort developed in 10/18 patients during iloprost administration; all but 1 were able to complete t

SUBMITTER: Rhodes J 

PROVIDER: S-EPMC4288936 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature