Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma.

ABSTRACT:

Background

Severe asthma remains poorly characterized, although it likely consists of at least 1 phenotype with features of TH2-like inflammation. IL1RL1, encoding both the IL-33 receptor, ST2L, and decoy receptor, sST2, has been genetically associated with asthma, though the mechanism for susceptibility remains unknown.

Objective

Given previous data supporting a role for IL1RL1 in TH2 inflammation, we hypothesized that ST2L expression might be increased in TH2-like asthma and that expression levels would be associated with single nucleotide polymorphisms in IL1RL1, possibly explaining its genetic relationship with asthma. We also sought to evaluate the regulation of ST2L and sST2 in vitro.

Methods

Endobronchial brushings and biopsies were obtained and expression of S

SUBMITTER: Traister RS 

PROVIDER: S-EPMC4289095 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature