Genetic ancestry influences asthma susceptibility and lung function among Latinos.

ABSTRACT:

Background

Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.

Objective

To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.

Methods

We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in e

SUBMITTER: Pino-Yanes M 

PROVIDER: S-EPMC4289103 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature