Computer-automated focus lateralization of temporal lobe epilepsy using fMRI.

ABSTRACT:

Purpose

To compare the performance of computer-automated diagnosis using functional magnetic resonance imaging (fMRI) interictal graph theory (CADFIG) to that achieved in standard clinical practice with MRI, for lateralizing the affected hemisphere in temporal lobe epilepsy (TLE).

Materials and methods

Interictal resting state fMRI and high-resolution MRI were performed on 14 left and 10 right TLE patients. Functional topology measures were calculated from fMRI using graph theory, and used to lateralize the epileptogenic hemisphere using quadratic discriminant analysis. Leave-one-out cross-validation prediction accuracy of CADFIG was compared to performance based on expert manual analysis (MA) of MRI, using video EEG as the "gold standard" for focus lateralization.

Result

SUBMITTER: Chiang S 

PROVIDER: S-EPMC4289130 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature