Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure.

ABSTRACT:

Background

Heart failure (HF), despite continuing progress, remains a leading cause of mortality and morbidity. P2X4 receptors (P2X4R) have emerged as potentially important molecules in regulating cardiac function and as potential targets for HF therapy. Transgenic P2X4R overexpression can protect against HF, but this does not explain the role of native cardiac P2X4R. Our goal is to define the physiological role of endogenous cardiac myocyte P2X4R under basal conditions and during HF induced by myocardial infarction or pressure overload.

Methods and results

Mice established with conditional cardiac-specific P2X4R knockout were subjected to left anterior descending coronary artery ligation-induced postinfarct or transverse aorta constriction-induced pressure overload HF. Knoc

SUBMITTER: Yang T 

PROVIDER: S-EPMC4289151 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature