Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.

ABSTRACT:

Importance

The association between red blood cell (RBC) transfusion strategies and health care-associated infection is not fully understood.

Objective

To evaluate whether RBC transfusion thresholds are associated with the risk of infection and whether risk is independent of leukocyte reduction.

Data sources

MEDLINE, EMBASE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, Cochrane Database of Sytematic Reviews, ClinicalTrials.gov, International Clinical Trials Registry, and the International Standard Randomized Controlled Trial Number register were searched through January 22, 2014.

Study selection

Randomized clinical trials with restrictive vs liberal RBC transfusion strategies.

Data extraction and synthesis

Twenty-one ran

SUBMITTER: Rohde JM 

PROVIDER: S-EPMC4289152 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature