Transcriptional response of Saccharomyces cerevisiae to potassium starvation.

ABSTRACT:

Background

Ion homeostasis is essential for every cell and aberrant cation homeostasis is related to diseases like Alzheimer's disease and epilepsy. The mechanisms responsible for cation homeostasis are only partly understood. The yeast Saccharomyces cerevisiae is an excellent organism to study fundamental aspects of cation homeostasis. In this study we investigated the transcriptional response of this yeast to potassium starvation by using Serial Analysis of Gene Expression (SAGE)-tag sequencing.

Results

Comparison of transcript levels in cells grown for 60 min in media without potassium with those in cells grown under standard potassium concentrations showed that the mRNA levels of 105 genes were significantly (P < 0.01) up-regulated more than 2.0-fold during potassium sta

SUBMITTER: Anemaet IG 

PROVIDER: S-EPMC4289377 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature