The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease.

ABSTRACT:

Objectives

This study sought to evaluate if diastolic pulmonary gradient (DPG) can predict survival in patients with pulmonary hypertension due to left heart disease (PH-LHD).

Background

Patients with combined post- and pre-capillary PH-LHD have worse prognosis than those with passive pulmonary hypertension. The transpulmonary gradient (TPG) and pulmonary vascular resistance (PVR) have commonly been used to identify high-risk patients. However, these parameters have significant shortcomings and do not always correlate with pulmonary vasculature remodeling. Recently, it has been suggested that DPG may be better a marker, yet its prognostic ability in patients with cardiomyopathy has not been fully assessed.

Methods

A retrospective cohort of 1,236 patients evaluated for

SUBMITTER: Tampakakis E 

PROVIDER: S-EPMC4289416 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature