Fetal exposure to maternal depressive symptoms is associated with cortical thickness in late childhood.

ABSTRACT:

Background

Maternal depression is one of the most common prenatal complications. The consequences of fetal exposure to maternal depression are poorly understood. The aim of this study is to examine the association between fetal exposure to maternal depressive symptoms and cortical thickness in children 6-9 years old.

Methods

A prospective, longitudinal study of maternal depressive symptoms at 19, 25, and 31 weeks' gestation was followed by acquisition of a structural magnetic resonance imaging scan in 81 children (age, 86.1 ± 9.9 months).

Results

Significant (p < .01) cortical thinning in children primarily in the right frontal lobes was associated with exposure to prenatal maternal depression. The strongest association was at 25 weeks' gestation; exposure to maternal

SUBMITTER: Sandman CA 

PROVIDER: S-EPMC4289467 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature