Neural correlates of inhibition and contextual cue processing related to treatment response in PTSD.

ABSTRACT: Thirty to fifty percent of posttraumatic stress disorder (PTSD) patients do not respond to treatment. Understanding the neural mechanisms underlying treatment response could contribute to improve response rates. PTSD is often associated with decreased inhibition of fear responses in a safe environment. Importantly, the mechanism of effective treatment (psychotherapy) relies on inhibition and so-called contextual cue processing. Therefore, we investigate inhibition and contextual cue processing in the context of treatment. Forty-one male war veterans with PTSD and 22 healthy male war veterans (combat controls) were scanned twice with a 6- to 8-month interval, in which PTSD patients received treatment (psychotherapy). We distinguished treatment responders from nonresponders on the base of pe

SUBMITTER: van Rooij SJ 

PROVIDER: S-EPMC4289955 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature