Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.

ABSTRACT:

Background

Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent.

Methods

We analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 persons, unselected for cancer or hematologic phenotypes. We identified somatic mutations on the basis of unusual allelic fractions. We used data from Swedish national patient registers to follow health outcomes for 2 to 7 years after DNA sampling.

Results

Clonal hematopoiesis with somatic mutations was observed in 10% of persons older than 65 years of age but in only 1% of those younger than 50 years of age. Detectable clonal expansions most frequently involved somatic mutat

SUBMITTER: Genovese G 

PROVIDER: S-EPMC4290021 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature