Depression and oxidative stress: results from a meta-analysis of observational studies.

ABSTRACT:

Objective

To perform a systematic review and meta-analysis that quantitatively tests and summarizes the hypothesis that depression results in elevated oxidative stress and lower antioxidant levels.

Methods

We performed a meta-analysis of studies that reported an association between depression and oxidative stress and/or antioxidant status markers. PubMed and EMBASE databases were searched for articles published from January 1980 through December 2012. A random-effects model, weighted by inverse variance, was performed to pool standard deviation (Cohen's d) effect size estimates across studies for oxidative stress and antioxidant status measures, separately.

Results

Twenty-three studies with 4980 participants were included in the meta-analysis. Depression was most comm

SUBMITTER: Palta P 

PROVIDER: S-EPMC4290164 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature