DCaP: detecting differential binding events in multiple conditions and proteins.

ABSTRACT:

Background

Current ChIP-seq studies are interested in comparing multiple epigenetic profiles across several cell types and tissues simultaneously for studying constitutive and differential regulation. Simultaneous analysis of multiple epigenetic features in many samples can gain substantial power and specificity than analyzing individual features and/or samples separately. Yet there are currently few tools can perform joint inference of constitutive and differential regulation in multi-feature-multi-condition contexts with statistical testing. Existing tools either test regulatory variation for one factor in multiple samples at a time, or for multiple factors in one or two samples. Many of them only identify binary rather than quantitative variation, which are sensitive to threshol

SUBMITTER: Chen KB 

PROVIDER: S-EPMC4290593 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature