Ontology highlight
ABSTRACT:
SUBMITTER: Mah TL
PROVIDER: S-EPMC4290611 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mah Tzia Liang TL Yap Xin Ning Adeline XN Limviphuvadh Vachiranee V Li Nanpu N Sridharan Srinath S Kuralmani Vellaisemy V Feng Mengling M Liem Natalia N Adhikari Sharmila S Yong Wei Peng WP Soo Ross A RA Maurer-Stroh Sebastian S Eisenhaber Frank F Tong Joo Chuan JC
BMC genomics 20141208
<h4>Background</h4>Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide due to poor patient prognosis and clinical outcome. Here, we studied the genetic variations underlying NSCLC pathogenesis based on their association to patient outcome after gemcitabine therapy.<h4>Results</h4>Bioinformatics analysis was used to investigate possible effects of POLA2 G583R (POLA2+1747 GG/GA, dbSNP ID: rs487989) in terms of protein function. Using biostatistics, POLA2+1747 GG/G ...[more]