Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis.

ABSTRACT:

Background

Transcriptome sequencing of brain samples provides detailed enrichment analysis of differential expression and genetic interactions for evaluation of mitochondrial and coagulation function of schizophrenia. It is implicated that schizophrenia genetic and protein interactions may give rise to biological dysfunction of energy metabolism and hemostasis. These findings may explain the biological mechanisms responsible for negative and withdraw symptoms of schizophrenia and antipsychotic-induced venous thromboembolism.

Results

Published BA22 RNA-Seq brain data of 9 schizophrenic patients and 9 controls samples were analyzed. The differentially expressed genes in the BA22 brain samples of schizophrenia are proposed as schizophrenia candidate marker genes (SCZCGs). The g

SUBMITTER: Huang KC 

PROVIDER: S-EPMC4290619 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature