CisMEP: an integrated repository of genomic epigenetic profiles and cis-regulatory modules in Drosophila.

ABSTRACT:

Background

Cis-regulatory modules (CRMs), or the DNA sequences required for regulating gene expression, play the central role in biological researches on transcriptional regulation in metazoan species. Nowadays, the systematic understanding of CRMs still mainly resorts to computational methods due to the time-consuming and small-scale nature of experimental methods. But the accuracy and reliability of different CRM prediction tools are still unclear. Without comparative cross-analysis of the results and combinatorial consideration with extra experimental information, there is no easy way to assess the confidence of the predicted CRMs. This limits the genome-wide understanding of CRMs.

Description

It is known that transcription factor binding and epigenetic profiles tend to d

SUBMITTER: Yang TH 

PROVIDER: S-EPMC4290730 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature