STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells.

ABSTRACT: Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The mechanism by which pancreatic cancer cells resist anoikis and metastasize is not well established. Significant proportion of pancreatic cancer cells resisted anoikis when grown under anchorage-independent conditions. The cells that resisted anoikis showed higher migratory and invasive characteristics than the cells that were cultured under anchorage-dependent condition. Interestingly, anoikis-resistant cells exhibited significantly increased expression and phosphorylation of signal transducer and activation of transcription 3 (STAT3) at Tyr 705, as compared to adherent cells. AG 490 and piplartine (PL) induced significant anoikis in anoikis-resistant pancreatic cancer cel

SUBMITTER: Fofaria NM 

PROVIDER: S-EPMC4291051 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature