Identification of genetic risk associated with prostate cancer using ancestry informative markers.

ABSTRACT:

Background

Prostate cancer (PCa) is a common malignancy and a leading cause of cancer death among men in the United States with African-American (AA) men having the highest incidence and mortality rates. Given recent results from admixture mapping and genome-wide association studies for PCa in AA men, it is clear that many risk alleles are enriched in men with West African genetic ancestry.

Methods

A total of 77 ancestry informative markers (AIMs) within surrounding candidate gene regions were genotyped and haplotyped using Pyrosequencing in 358 unrelated men enrolled in a PCa genetic association study at the Howard University Hospital between 2000 and 2004. Sequence analysis of promoter region single-nucleotide polymorphisms (SNPs) to evaluate disruption of transcription fa

SUBMITTER: Ricks-Santi LJ 

PROVIDER: S-EPMC4291058 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature