Ontology highlight
ABSTRACT:
SUBMITTER: De Cremer K
PROVIDER: S-EPMC4291436 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20141103 1
Mucosal biofilm-related fungal infections are very common, and the incidence of recurrent oral and vulvovaginal candidiasis is significant. As resistance to azoles (the preferred treatment) is occurring, we aimed at identifying compounds that increase the activity of miconazole against Candida albicans biofilms. We screened 1,600 compounds of a drug-repositioning library in combination with a subinhibitory concentration of miconazole. Synergy between the best identified potentiators and miconazo ...[more]