Early and late age of seizure onset have a differential impact on brain resting-state organization in temporal lobe epilepsy.

ABSTRACT: Temporal lobe epilepsy (TLE) is associated with abnormalities which extend into the entire brain. While the age of seizure onset (SO) has a large impact on brain plasticity, its effect on brain connectivity at rest remains unclear, especially, in interaction with factors such as the presence of mesial temporal sclerosis (MTS). In this context, we investigated whole-brain and regional functional connectivity (FC) organization in 50 TLE patients who underwent a resting-state fMRI scan, in comparison to healthy controls, using graph-theory measures. We first classified TLE patients according to the presence of MTS or not. Then, we categorized the patients based on their age of SO into two subgroups (early or late age of SO). Results revealed whole-brain differences with both reduced functiona

SUBMITTER: Doucet GE 

PROVIDER: S-EPMC4291512 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature